Rabbi Shmuel Kaminezki was born in Kfar Chabad, Israel in 1965. In 1946, his parents fled the Soviet Union to the Land of Israel due to religious persecution and Anti-Semitism.

In 1981 Rabbi Kaminezki moved to the United States to study at the Rabbinical College of America-Lubavitch in Morristown, NJ. He continued his education and taught at a yeshiva for emissaries in New Haven, CT as well as at the Rabbinical College of America-Lubavitch. In 1988 he received his rabbinical ordination.

In 1989 he married Chana Lipsker.

In 1990, the Lubavitcher Rebbe Menachem Mendel Schneerson sent Rabbi Shmuel and Chana Kaminezki to the Jewish community of Dnepropetrovsk as emissaries.

Rabbi Kaminezki is currently the Chief Rabbi of Dnipro and Dnepropetrovsk Region, Chairman of the Board of the Dnepropetrovsk Jewish community. Rabbi Shmuel and Chana Kaminezki have six daughters and three sons and nine grandchildren.